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Its central mechanism of action provides pain relief with lower risks of stomach and cardiovascular problems compared to NSAIDs, though liver toxicity remains a serious concern with overdose or in susceptible individuals

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Immunohistochemical assessment The iNOS and eNOS immunohistochemical findings were assessed using the percentages of immunopositive cells (brown cytoplasmic staining), which were divided into five groups as follows: 0 (all cells are negative), 1 ( 76% positive cells)